<aside> <img src="https://s3-us-west-2.amazonaws.com/secure.notion-static.com/96605d37-eae6-4195-bd2a-ba0b757593a7/Make_a_fruit_fly_with_single_black_line_logo.svg" alt="https://s3-us-west-2.amazonaws.com/secure.notion-static.com/96605d37-eae6-4195-bd2a-ba0b757593a7/Make_a_fruit_fly_with_single_black_line_logo.svg" width="40px" /> Paracrine Signaling in Tissue Organization Lab
</aside>
<aside> 🇧🇷 Português
</aside>
<aside> <img src="https://s3-us-west-2.amazonaws.com/secure.notion-static.com/06375b57-bd5c-482e-bd8e-d0cae4acbaff/Make_a_fruit_fly_with_single_black_line_logo.svg" alt="https://s3-us-west-2.amazonaws.com/secure.notion-static.com/06375b57-bd5c-482e-bd8e-d0cae4acbaff/Make_a_fruit_fly_with_single_black_line_logo.svg" width="40px" /> Home | Research | Teaching | Extension | Drosophila melanogaster
</aside>
The project led by Professor Guilherme Oliveira Barbosa in the Paracrine Signaling in Tissue Organization laboratory focuses on understanding how certain molecules, called heparan sulfate proteoglycans (HSPGs), play a crucial role in cell communication within the body. These communications are essential for the development, survival, and healthy aging of animals.
HSPGs are involved in specific signaling pathways that help cells communicate with each other. The study will use fruit flies (Drosophila melanogaster) to observe these processes. The research focuses on fundamental questions about how cells release signaling molecules and whether this release depends on HSPGs. Additionally, we will investigate whether HSPGs have specific functions within cells that produce signaling molecules.
<aside> <img src="/icons/thought-dialogue_red.svg" alt="/icons/thought-dialogue_red.svg" width="40px" /> What's on our minds all the time?
The results of this study can provide new insights into how cells communicate and how it affects the development and health of animals. The use of fruit flies as a model simplifies research with this powerful genetic tool, allowing for valuable insights that may eventually contribute to understanding biological processes in complex organisms, such as humans.
**droso4schools**
Barbosa, G.O., and Kornberg, T.B. (2022). Protocol for ex vivo time lapse imaging of Drosophila melanogaster cytonemes. STAR Protocols 3, 101138. LINK
Hatori R, Wood BM, Oliveira Barbosa G, Kornberg TB. Regulated delivery controls Drosophila Hedgehog, Wingless, and decapentaplegic signaling. Elife. 2021 Jul 22;10:e71744. LINK
Barbosa GO, Augusto TM, Bruni-Cardoso A, Carvalho HF. The role of SDF1 in prostate epithelial morphogenesis. J Cell Physiol. 2019 May;234(5):6886–97. LINK
Barbosa GO, Bruni-Cardoso A, da Silva Pinhal MA, Augusto TM, Carvalho HF. Heparanase-1 activity and the early postnatal prostate development. Dev Dyn. 2019 Mar;248(3):211–20. LINK
List of papers: https://orcid.org/0000-0002-5881-0896